|
KMID : 1161420220250060645
|
|
Journal of Medicinal Food
2022 Volume.25 No. 6 p.645 ~ p.651
|
|
|
Effect of Momordica charantia Administration on Anthropometric Measures and Metabolic Profile in Patients with Obesity: A Pilot Clinical Trial
|
|
Cortez-Navarrete Marisol
Villar Miriam Mendez-del
Martinez-Abundis Esperanza
Lopez-Murillo Luis D.
Escobedo-Gutierrez Miriam de J.
Rosales-Rivera Lizet Y.
Perez-Rubio Karina G.
|
|
|
Abstract
|
|
|
|
The aim of this study was to evaluate the effect of Momordica charantia (MC) administration on anthropometric measures in patients with obesity. A randomized, double-blind, placebo-controlled pilot clinical trial was carried out in 24 patients with obesity. Twelve patients randomly received MC (2000?mg/day) for 12 weeks, and 12 patients received placebo. Body weight (BW), body mass index (BMI), waist circumference (WC), body fat percentage, as well as clinical and laboratory determinations, were evaluated before and after the intervention. Results showed that while reductions in BW, BMI, WC, and body fat percentage were observed in the MC group, these differences did not reach statistical significance. Significant decreases in triglycerides (TG) (1.9?±?0.6?mM vs. 1.7?±?0.7?mM, P?≤?.05) and very low-density lipoprotein (VLDL) (0.4?±?0.1?mM vs. 0.3?±?0.1?mM, P?≤?.05) levels were found after the intervention with MC. In contrast, significant increases in BW (83.0?±?10.7?kg vs. 84.6?±?9.1?kg, P?≤?.05) and BMI (31.9?±?1.5?kg/m2 vs. 33.0?±?1.3?kg/m2, P?≤?.05) were observed in the placebo group. In conclusion, no significant reductions in BW, BMI, WC, and body fat percentage were observed after MC administration; however, MC significantly decreased TG and VLDL levels. The protocol was registered at ClinicalTrials.gov with the identifier NCT04916379.
|
|
|
KEYWORD
|
|
|
anthropometric measures, bitter melon, medicinal plant, metabolic profile, Momordica charantia, obesity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|